This book assembles recent achievements in both basic research and clinical man_x005f_x005f_x005fagement in the field of hepatology, virology, and immunology. It provides up-todate information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology and state-of-the-art treatment strategies provided in this book serve as references for clinicians and resident p
內容簡介：
This book assembles recent achievements in both basic research and clinical management in the field of hepatology, virology, and immunology. It provides up-to-date information for clinicians who can apply the relevant knowledge to their dailyclinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology and state-of-the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the daily management of ACLF. The rationality and strategies for basic research as well as patient management in this book can also be a valuable reference for other fatal and end-stage liver diseases than HBV-induced ACLF.
This Volume 1 has six chapters and focuses on the definition, research technology, virology, genetics, and immunology.
This book assembles recent achievements in both basic research and clinical management in the field of hepatology, virology, and immunology. It provides up-to-date information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology and state-of-the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the daily management of ACLF.The rationality and strategies for basic research as well as patient management in this book can also be a valuable reference for other fatal and end-stage liver diseases than HBV-induced ACLF.
This Volume 1 has six chapters and focuses on the definition, research technology, virology, genetics, and immunology.
宁琴教授为传染病学、免疫学教授，传染病学主任医师，博士生导师，国家杰出青年科学基金获得者（2002年）,科技部973重大传染病专项首席科学家（2007年），国家十二五十三五传染病重大专项牵头人（20132017年），教育部长江学者和创新团队发展计划创新团队牵头人（2012年），享受国务院政府特殊津贴专家，卫生部有突出贡献中青年专家，华中科技大学华中学者领军岗（2012年）。为华中科技大学首批受聘国家二级教授。现任华中科技大学同济医学院附属同济医院传染病学教研室主任、感染科主任、感染性疾病研究所所长。获 湖北省青年岗位能手称号、湖北省青年科技奖和上海宝钢教育奖（优秀教师）、武汉市十大杰出青年和武汉市三八红旗手标兵称号。宁琴教授主要从事肝脏疾病包括慢性病毒性肝炎、脂肪肝、肝纤维化、重型肝炎和肝癌的基础研究与临床、教学工作近30年。近年来发表论文300余篇，其中SCI论文276篇，被引2553次（他引1933）（2018年5月），包括JCI， J Immunology, JBC, Human Gene Therapy，Liver International, Journal of Hepatology, Antiviral Therapy，Biol Chem等。发明专利6项。
目錄：
1 Introduction to Acute Exacerbation of Chronic
Hepatitis B AECHB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Qin Ning, Di Wu, Wei Guo, Wei-Na Li, Xiao-Jing Wang, and Ke Ma
2 Research Methods and Techniques for Acute Exacerbation of
Chronic Hepatitis B . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Zhi Chen, Dong Xu, Tao Chen, Dao-Feng Yang, and Yi-Min Mao
3 Virological Factors Involved in AECHB . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Hong Tang, Mei-Fang Han, and Yi-Ming Zhang
4 Host Genetic Characters of Acute Exacerbation of
Chronic Hepatitis B AECHB. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159
Yu-Ming Wang, Jun-Qi Niu, Guo-Hong Deng, and Ying-Ren Zhao
5 Immunological Features of AECHB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Ping Lei, Guan-Xin Shen, Fu-Sheng Wang, Qin Ning, Hong Ren,
Wei-Ming Yan, and Di Wu
6 Other Precipitating Factors for AECHB . . . . . . . . . . . . . . . . . . . . . . . . . 315
Bao-Hong Wang, Jing Guo, Lan-Juan Li, Tao Chen, Chun-Xia Guo,
and Yong-Wen He1 Clinical Manifestations and Laboratory Tests of AECHB
and Severe Hepatitis Liver Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Liang Peng, Zhi-Liang Gao, Yu-Ming Wang, Deng-Ming He,
Jin-Ming Zhao, Xue-Fan Bai, and Xiao-Jing Wang
2 Main Complications of AECHB and Severe
Hepatitis B Liver Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
Jian-Xin Song, Lin Zhu, Chuan-Long Zhu, Jin-Hua Hu, Zijian Sun,
Xiang Xu, Min-You Xin, Qiong-Fang Zhang, Da-Zhi Zhang,
Jia Shang, Jia-Quan Huang, and Dong Xu
3 Early Prognostic Predictive System of AECHB
and the Diagnosis of Severe Hepatitis B Liver Failure . . . . . . . . . . . . . 227
Zhi Chen, Qin Ning, and Guang Chen
4 Treatment of AECHB and Severe Hepatitis Liver Failure . . . . . . . . . . 273
Yu-Ming Wang, Ke Li, Xiao-Guang Dou, Han Bai, Xi-Ping Zhao,
Xiong Ma, Lan-Juan Li, Zhi-Shui Chen, and Yuan-Cheng Huang
5 Antiviral Therapy for AECHB and Severe
Hepatitis B Liver Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 371
Qin Ning, Ting Wu, Hai-Bing Su, Ke Ma, Jun-Ying Qi,
Ming Ni, and Di Wu
6 Prognosis, Prevention and Research Prospects
of Progression to Severe Hepatitis B Liver Failure . . . . . . . . . . . . . . . . 457
Yu-Ming Wang, Dao-Feng Yang, Ming Wang, Nazia Selzner, Kaveh
Farrokhi, Andrzej Chruscinski, and Gary Levy
內容試閱：
It is now recognized that as a consequence of chronic HBV infection, many patients
with or without established cirrhosis will develop acute decompensation and multi_x005forgan failure, a syndrome known as acute-on-chronic liver failure ACLF. Once
patients develop ACLF, they are at high risk of death. A number of triggers including reactivation of HBV, coinfection of hepatitis A or E virus, onset of bacterial
infection, gastrointestinal bleeding and development of renal dysfunction can precipitate the development of ACLF in patients who have been previously stable.
ACLF is prevalent in Asia where many patients have incubative chronic hepatitis B
virus HBV infection.
For the past decade, with an increasing understanding of the disease mechanisms
and improved general internal medications, the overall mortality has significantly
decreased due to HBV infection-related ACLF HBV-ACLF in Chinese patients.
Here we have assembled a group of hepatologists and scientists from academic
hospitals and universities to explore the current understanding of the clinical,
genetic, virologic and immunologic factors that contribute to ACLF.In this book of
12 chapters, we have explored the current state of knowledge of HBV infection with
a specific focus on the natural history and the clinical course to define important
host and viral factors to the development of ACLF, sharing our profound experience
and clinical procedures in early diagnosis and treatment of HBV-ACLF patients and
its complications. All together about 2649 references have been cited, of which 754
were since 2012. At the beginning of the book, there is a complete table of contents,
which together with the general index makes it possible for the reader to find specific topics easily. In each chapter, there is an abstract for the reader to gain a quick
information of the chapter. We have also used 55 coloured figures to make the illus_x0002_trations even more visual.
We enlisted the helpful advice of friends, colleagues and senior experts to supplement or confirm our own interpretations. The contacts arising from these discussions have been immensely benignant to me. Here my special thanks to Prof. Gary
Levy, Prof. Didier Samuel, Prof. Gyongyi Szabo, Prof. Lanjuan Li, Prof. Zhimeng
Lu, Prof. Shiv Kumar Sarin, Prof. Stephen Locarnini, Prof. Xinhua Weng, Prof.
Yuquan Wei and Prof. Hui Zhuang.
Finally I should express my gratitude to the employees at HUST Press and
Springer Publishing House Mr. James Hu for their professional help in completing
this book, especially to Ms. Lian-Di Wang, senior editor, and Mr. Wei Che, projector manager, who gave their kind support at all times.
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